The Deadliest U.S. Hurricanes A list of the most deadly hurricanes that affected the United States. Note that some number are estimates. Hurricanes are ranked in number of estimated lives lost. Rank Hurricane Name Year Category Deaths 1 Galveston, TX 1900 4 8000 2 Lake Okeechobee, FL 1928 4 2500 3 Katrina 2005 3 1500 4 Cheniere Caminanda, LA 1893 4 1100-1400 5 Sea Islands, GA/SC 1893 3 1000-2000 6 GA/SC 1881 2 700 7 Audrey 1957 4 416 8 "Keys Labor Day" 1935 5 408 9 Last Island, LA 1856 4 400 10 Miami, FL 1926 4 372 Join in on our travel and weather discussions on our travel and weather message boards.